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Mailbag: Implants, Creatine, Barbells And The Window

Four questions in focus this week, drawn from the last fortnight of issues and answered straight from the papers. Every answer is held to what the trials can actually carry.

Four questions in focus.

These are the ones worth putting to the papers this week.

Every answer here stays inside what the trials can carry.

Three of the four are mostly about limits…

// Mailbag 01

“Can I get one of these brain implants, or is it all trial work?”

Trial work, all of it.

The speech decoders live in four people at Stanford. One man runs another in California.

Just one device has been cleared for sale. China’s regulator did that on 13 March 2026. It drives a robotic glove for hand movement after spinal cord injury.

Speech is not part of it. So there is nothing to buy yet, and no waiting list to join.

↗ Source: Fierce Biotech, 2026

// Mailbag 02

“I am 47. Is creatine worth it for my memory?”

For muscle, yes. For memory at 47, nobody knows.

Its authors recounted their own pool… and agreed. The gain that survived sits in adults of 66 to 76.

In younger adults the same recount came out at 0.02, which is nothing.

At 47 you sit in the untested middle. Five grams is cheap, and it is safe. Buy it for the muscle case… and treat any memory gain as a bonus nobody has measured.

↗ Source: the authors’ reply, Nutrition Reviews, 2023

// Mailbag 03

“Is lifting enough for my bones, or do I need the drug?”

They are answers to different questions.

Eight months of heavy lifting put 2.9% on the spine in women past menopause. Controls lost 1.2% over the same stretch.

The antibody put 12.7% on the spine over a year, and cut fractures. It also carries a boxed warning on heart attack and stroke. The course stops at twelve doses.

One is a habit for a healthy frame. The other is a prescription, usually after a break has already happened.

I found no trial that ran them head to head.

↗ Source: Watson, Journal of Bone and Mineral Research, 2018

↗ Source: Cosman, New England Journal of Medicine, 2016

// Mailbag 04

“I train fasted at six in the morning. Does the window matter for me?”

Here the papers run out before your question does.

The pooled analysis matched total daily protein. That took the timing effect with it.

But the direct test used trained men. They fasted three hours on one side of the session, which is not a night.

A dawn session on an empty stomach is not in that set.

What is tested is the daily number. Hit that, and the hour is yours to choose.

↗ Source: Schoenfeld, JISSN, 2013

↗ Source: Schoenfeld, PeerJ, 2017

// Your Pick

Which answer was most use to you?

Pick one and hit send.

🧠 The implants
 
🧺 Creatine at 47
 
🏋 Bar against drug
 
⏰ The window

// The Log

What I Actually Ran

Five by five on the bar, Tuesday and Friday, eight weeks in now.

01 Creatine at five grams, in the morning coffee.
02 Protein counted once, then eaten whenever the day allowed.
03 No hard landings yet, because my knees have opinions.
04 Nothing measured but the bar, and no blood test to go with it.
05 One man, no control group, and a sample size of me.

// Talk To Me

What should I put in focus next?

↗ Hit Reply

Stay primal,
Dex

Primal Code

// Read Next

More from the desk

View all issues

Call Yourself By Name Before You Speak

Eighty nine students had five minutes to prepare a speech for a panel they were told would judge them. The ones who coached themselves by name came out in better shape, and blind coders scored their speeches higher.

Read issue ↗
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